pentobarbital will reduce the extent or impact of buprenorphine buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will decrease the extent or effect of repaglinide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

pentobarbital will decrease the level or impact of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Mysterious.

pentobarbital will minimize the extent or impact of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

pentobarbital will lower the extent or effect of estradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

Pursuing oral or parenteral administration, barbiturates easily cross the placental barrier and therefore are distributed through fetal tissues with maximum concentrations located in the placenta, fetal liver, and Mind; fetal blood stages approach maternal blood amounts next parenteral administration

pentobarbital will decrease the extent or result of clozapine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

lasmiditan, pentobarbital. Either improves effects of check here the opposite by sedation. Use Caution/Keep an eye on. Coadministration of lasmiditan along with other CNS depressant drugs, which includes Alcoholic beverages haven't been evaluated in clinical studies. Lasmiditan could lead to sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

Stay clear of; coadministration with CYP3A inducers might cause lowered plasma concentrations of elvitegravir and/or maybe a concomitantly administered protease inhibitor and result in loss of therapeutic effect also to achievable resistance

pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Warning/Keep an eye on. Drugs that increase delta-aminolevulinic acid synthetase may possibly decrease hemin result.

pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Might bring on lack of virologic reaction and probable resistance.

pentobarbital will decrease the extent or effect of felodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

Barbiturates can induce hepatic microsomal enzymes causing enhanced metabolism and decreased anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); people stabilized on anticoagulant therapy could involve dosage adjustments if barbiturates are extra to or withdrawn from their dosage program

pentobarbital will lessen the level or influence of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.